Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.
By I. Winkler, N. Sims, A. Pettit, V. Barbier, B. Nowlan, Falak M Helwani, Ingrid J. Poulton, N. Van Rooijen, Kylie A Alexander, L. Raggatt and 1 more. Blood, 2010
811 citations recorded by the source corpus.
Subfields: Genetics, Hematology, Immunology
View Paper: https://www.semanticscholar.org/paper/62aff4d8b81ce5d6b1a80f1ef35ccb2eb5c97314
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Citations in the corpus
- Rhythmic modulation of the hematopoietic niche through neutrophil clearance (2013, positive): “Macrophages have been shown to support the function of the hematopoietic niche through the production of undefined protein factors (Chow et al., 2011; Winkler et al., 2010).”
- Mesenchymal stem cell-macrophage crosstalk and bone healing (2018, neutral): “Firstly, neither the MAFIA model nor clodronate liposome depletion is entirely specific to macrophages, but could also impact other closely-related cells of the myeloid lineage, importantly osteoclasts [23, 33-35] As both osteoclasts and macrophages play distinct roles in bone regeneration, determin”
- Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche (2011, methodology): “We sorted CD45 Ter119 Nestin+ and CD45 Ter119 Nestin from the BM and CD45 Ter119 CD31 Sca-1 CD51+ osteoblasts (Semerad et al., 2005; Winkler et al., 2010) from the bone 14 h or 7 d after depletion (Fig.”
- The crucial roles of inflammatory mediators in inflammation: A review (2018, background): “The latter is released into blood circulation from its manufacturer (bone marrow) after some sophisticated steps (Figure-2) [78,79].”