AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

By Haihong Zong, Jianming Ren, L. Young, M. Pypaert, J. Mu, M. Birnbaum, Gerald I. Shulman. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,083 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/413cfabde7f3109053e50ae4a7f9694ae35b51e4

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Citations in the corpus

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. (2004, methodology): “microscopy as previously described (14) to examine cardiac morphol-”
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “…expression of PGC1a came from studies of mice expressing a dominantnegative mutant of AMPK, in which the induction of mitochondrial DNA and PGC-1a mRNA in response to the feeding of b-guanidinopropionic acid (a creatine analog that causes ATP depletion) was abolished (Zong et al. 2002).”
Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. (2005, background): “Moreover, it was demonstrated that increase in the PGC-1 level and the mitochondrial abundance are dependent on the activities of CAMKIV (Wu et al., 2002) and AMP kinases (Zong et al., 2002), which are regulated by changes in intracellular Ca2+ concentrations and the ATP/AMP ratio, respectively.”
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. (2005, positive): “For each set of 5 pictures, average volume density was calculated and the mean of 3 values used to estimate the volume density for each individual muscle (34).”
Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice (2009, background): “phosphorylate the PGC-1α protein and inhibit its degradation (27; 28; 31-34).”
The AMP-activated protein kinase pathway – new players upstream and downstream (2004, background): “…the expression of the co-activator PGC1α (Terada et al., 2002), which may be involved in the increased expression of mitochondrial genes in muscle (Zong et al., 2002), yet it downregulates the transcription factors SREBP-1c (Zhou et al., 2001) and HNF4α (Leclerc et al., 2001; Hong et al.,…”
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (2005, background): “, 2004), increased mitochondrial biogenesis (Zong et al., 2002), and possibly glucose uptake (Mu et al.”