Rapamycin alleviates toxicity of different aggregate-prone proteins.

By Z. Berger, B. Ravikumar, Fiona M Menzies, L. Oroz, B. Underwood, M. Pangalos, I. Schmitt, U. Wullner, B. Evert, Cahir O'Kane and 1 more. Human Molecular Genetics, 2006

682 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/40df178ba992e2e2e8bfa9dde7d3f50c022ccd14

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Citations in the corpus

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies (2016, background): “, by rapamycin that induces macroautophagy [175], inhibitors of Hsp90 chaperone protein that binds to misfolded proteins or by immunotherapeutic approaches [176].”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “…microscopy - the reduction of the large aggregates after autophagy induction may reflect a reduced input of the smaller species into the aggregates and the flux of the mutant proteins on and off the aggregates (Berger et al., 2006; Ravikumar et al., 2002; Ravikumar et al., 2004; Webb et al., 2003).”
Role of autophagy in cancer (2007, neutral): “, and aggregation-prone proteins and protein aggregate”
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. (2009, background): “Up to now, the degradation of Tau by the ubiquitin–proteasome system has been investigated by several authors (13,14,16,17,20), whereas the involvement of the autophagy–lysosome system has received less attention (23,31,38).”
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. (2007, methodology): “Although these SMIRs and SMERs were discovered as modulators of the effects of rapamycin on yeast growth, we tested if they were also modulators of mammalian autophagy.”
Mechanisms of Selective Autophagy (2016, positive): “Rapamycin treatment promoted the clearance of aggregated proteins by autophagy in mammalian cell lines and Drosophila melanogaster [111].”