Double-strand break end resection and repair pathway choice.

By L. Symington, J. Gautier. Annual Review of Genetics, 2011

1,465 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/407a9a16706c575c75d42a2b1ce64a925877daf1

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In Cancer Research

1. Rodney Rothstein
2. J. R. Chapman
3. S. Boulton
4. Jinxing Liu
5. Caixia Gao
6. L. Zou
7. Yanpeng Wang
8. M. Jasin

In Molecular Biology

1. Caixia Gao
2. Feng Zhang
3. Yanpeng Wang
4. Kunling Chen
5. Rodney Rothstein
6. R. Jaenisch
7. A. Cheng
8. J. R. Chapman

Citations in the corpus

• A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. (2013, background): “…in NHEJ is consistent with the observation that 53BP1 deletion in mouse results in a severe defect in class-switch recombination (CSR), an NHEJ-dependent process, which is accompanied by increased DNA end resection at the IgH locus (Bunting et al., 2012; Manis et al., 2004; Ward et al., 2004).”
• Playing the end game: DNA double-strand break repair pathway choice. (2012, background): “A major restriction point in the choice between DSB repair pathways is in the competition between DNA end protection andDNA end resection (Symington and Gautier, 2011).”
• Repair of strand breaks by homologous recombination. (2013, background): “As a key early step in HR reactions, the generation of 30 single-stranded DNA by resection of the 50 end acts as a control point for DSB repair pathway choice (Kass and Jasin 2010; Symington and Gautier 2011).”
• One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering (2013, positive): “…flanking the DSB (see Figure S2B) consistent with previous reports demonstrating that perfect microhomology sequences flanking the cleavage sites can generate microhomology-mediated precise deletions by end repair mechanism (MMEJ) (McVey and Lee, 2008; Symington and Gautier, 2011) (Figure S2B).”
• DNA damage sensing by the ATM and ATR kinases. (2013, background): “Based on studies using yeast, Xenopus, and human cells, several conserved nucleases have been implicated in the generation of ssDNA at DSBs through a process called resection (Symington and Gautier 2011).”
• RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection (2013, background): “While many genetic observations in yeast attribute resection inhibition largely to the dsDNA end-binding Ku-heterodimer (Ku) (reviewed in Symington and Gautier, 2011), recent evidence in mice indicates that 53BP1 asserts much more of a repressive effect on this activity than Ku (Bunting et al.,…”
• Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew (2014, positive): “…zinc-finger nucleases (ZFNs) 10 , TALENs, and the RNA-guided nuclease Cas9 (CRISPR-Cas9 system), have been developed to generate targeted DNA double-strand breaks, which are then repaired mainly by either error-prone non-homologous end joining (NHEJ) or high-fidelity homologous recombination 11 .”