A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

By Cristina Escribano-Díaz, Alexandre Orthwein, Amélie Fradet-Turcotte, Mengtan Xing, J. Young, J. Tkáč, Michael A. Cook, Adam P. Rosebrock, Meagan M. Munro, M. Canny and 2 more. Molecules and Cells, 2013

885 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1bce3c5870847c34a09ee36d1acbd85ddcfd56e1

How researchers see this paper

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In Molecular Biology

1. Rodney Rothstein
2. Weiran Feng
3. Yu Zhang
4. Rohit Prakash
5. M. Jasin

In Oncology

1. M. Jasin

Citations in the corpus

• Repair of strand breaks by homologous recombination. (2013, background): “Like HR and SSA, alt-NHEJ at microhomology is suppressed by canonical NHEJ components like Ku and LIG4/XRCC4, but it can also operate in the presence of the canonical pathway (Weinstocket al. 2007; Simsek and Jasin 2010; Simsek et al. 2011; Escribano-Diaz et al. 2013).”
• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “…BRCA1 and 53BP1 at DSBs has been shown to be regulated by acetylation of histone H4K20me2, which interferes with 53BP1 binding (Tang et al. 2013) and also involves RIF1, which binds ATM-phosphorylated 53BP1 (Chapman et al. 2013; Escribano-Diaz et al. 2013; Feng et al. 2013; Zimmermann et al. 2013).”