The Many Faces of Tau
By Meaghan Morris, Sumihiro Maeda, Keith A. Vossel, L. Mucke. Neuron, 2011
899 citations recorded by the source corpus.
Summary While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.
Subfields: Cellular and Molecular Neuroscience, Geometry and Topology, Physiology
View Paper: https://www.semanticscholar.org/paper/40e16d5ca9b567ca46153189874575a39e92b33a
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In Cellular and Molecular Neuroscience
In Geometry and Topology
In Physiology
- L. Mucke
- D. Selkoe
- E. Mandelkow
- R. Deane
- Maiken Nedergaard
- Itender Singh
- Jeffrey J. Iliff
- D. Holtzman
Citations in the corpus
- Biochemistry and cell biology of tau protein in neurofibrillary degeneration. (2012, background): “A number of excellent reviews on the biology and pathology of Tau have appeared over the past few years (Cassimeris and Spittle 2001; Garcia and Cleveland 2001; Terwel et al. 2002; Dehmelt and Halpain 2005; Andreadis 2006; Ballatore et al. 2007; Gotz et al. 2007, 2010; Iqbal and Grundke-Iqbal 2008; ”
- Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. (2012, background): “Examples of the latter strategies include reductions in the levels of the microtubuleassociated protein tau (Roberson et al. 2007, 2011; Ittner et al. 2010; Jin et al. 2011; Morris et al. 2011) or of GIVA-PLA2, (Sanchez-Mejia et al.”
- Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies (2016, background): “The projection domain of tau may be involved in cell signaling that occurs through the interaction with Lck, Fgr and cSrc (Src-family kinases), growth factor receptor-bound protein 2 (Grb2), phospholipase C-γ [70], phosphatidylinositol and phosphatidylinositol bisphosphate [71,72], peptidyl-prolyl c”
- Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury (2014, background): “After brain injury, including TBI, high levels of tau are released into the brain ISF and CSF (Morris et al., 2011; Magnoni et al., 2012; Tsitsopoulos and Marklund, 2013), presumably as a result of axonal damage.”