PRDM16 controls a brown fat/skeletal muscle switch

By P. Seale, B. Bjork, Wenli Yang, S. Kajimura, Sherry Chin, S. Kuang, A. Scimè, S. Devarakonda, Heather M. Conroe, H. Erdjument‐Bromage and 4 more. Nature, 2008

2,354 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4042587ca521dc21e3e2ebe5f5d39adbd635323d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Spiegelman
2. Navdeep S. Chandel
3. P. Seale
4. H. Ohno
5. Jun Wu
6. Kosaku Shinoda
7. Toren Finkel
8. James P. White

In Cell Biology

1. B. Spiegelman
2. J. Hawley
3. Jun Wu
4. Richard A. Young
5. Kosaku Shinoda
6. P. Seale
7. Toren Finkel
8. Navdeep S. Chandel

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Jun Wu
5. C. Bentzinger
6. J. Hawley
7. P. Cohen
8. Mitchell A. Lazar

Citations in the corpus

• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “Agonist treatment was shown to lead to deacetylation of PPARg, which is dependent on the NADdependent deacetylase SirT1 (Qiang et al. 2012).”
• Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis (2010, methodology): “The same strategy was recently used to show that brown fat and muscle share developmental origin”
• Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, positive): “…and regulate gene expression (Ptashne, 1988), and master transcription factors are required for establishment, maintenance, and even reprogramming of cell identity (Takahashi and Yamanaka, 2006; Feng et al., 2008; Lassar et al., 1986; Seale et al., 2008; Zhou et al., 2008; Graf and Enver, 2009).”
• In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high fat feeding (2012, neutral): “In this regard, tracing studies have established that BA in conventional brown adipose depots, such as the interscapular pad, arise from myogenic Myf5 progenitors, but those induced to appear in WAT do not (Seale et al., 2008).”
• Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis (2014, background): “…5Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 2AJ, UK 6Ember Therapeutics, Inc., 480 Arsenal Street, Building 1, Suite 101, Watertown, MA 02472, USA *Correspondence: bruce_spiegelman@dfci.harvard.edu http://dx.doi.org/10.1016/j.cell.2014.03.065”
• Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “Interestingly, lineage-tracing studies ( Box 1 ) have revealed that BAT is more closely related to skeletal muscle than WAT, as both muscle and BAT have progenitors that express the early muscle marker myogenic factor 5 (MYF5) but WAT does no”
• Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “Together, these observations are consistent with the link between brown fat and skeletal muscle (Seale et al., 2008).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “Furthermore, histological analyses showed that a new beige cell marker, CITED1, was selectively expressed in the UCP1-positive beige cells as well as in human BAT.”