Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila

By Julien Séjourné, P. Plaçais, Yoshinori Aso, Igor Siwanowicz, Severine Trannoy, Vladimiros Thoma, S. R. Tedjakumala, Gerald M. Rubin, P. Tchénio, Kei Ito and 3 more. 2011

269 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Immunology

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “We observed broad potentiation of KC-MBON synapses after DAN activation but odor-specific depression if DANs were coincidently activated with KCs, consistent with the synaptic changes previously proposed to occur after learning (Aso et al., 2014b; Owald et al., 2015; Séjourné et al., 2011).”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Consistent with this mechanism, the PE1 MBONs in honeybees (Okada et al., 2007) as well as the V2 cluster MBONs in Drosophila (Sejourne et al., 2011) reduce their response to a learned odor and depression of KC-MBON synapses has been shown for octopamine modulation in the locust MB (Cassenaer and La”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “Genetic manipulation has also implicated specific subsets of MBONs in the mediation of learned appetitive and aversive behaviors (Sejourne et al., 2011; Pai et al., 2013; Placais et al., 2013; Aso et al., 2014).”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…al., 2014; Tomchik and Davis, 2009; Wang et al., 2008; Yu et al., 2006, but see Zhang and Roman, 2013), signals in MBONs decrease in some cases (Owald et al., 2015; Séjourné et al., 2011) and increase in others (Bouzaiane et al., 2015; Owald et al., 2015; Pai et al., 2013; Plaçais et al., 2013).”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…are being worked out in detail (Aso et al., 2014b; Chen et al., 2012; Cohn et al., 2015; Hige et al., 2015a; Hige et al., 2015b; Owald et al., 2015; Sejourne et al., 2011), our study provides a timely addition to the mushroom body literature – a way forward from neural circuit to molecular…”
Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. (2013, methodology): “MB-V2 neurons, efferent neurons from the MB vertical lobes, are required for the retrieval of aversive memory (Séjourné et al., 2011).”
Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. (2015, methodology): “Conversely, M4/M6 neurons are dispensable for the retrieval of LTM 24 hr after spaced training (Figures S5M and S5N), contrary to V2 neurons (Séjourné et al., 2011; Aso et al., 2014b).”
A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “DANs that project to the other a lobe compartments, a2 and a3, play roles in aversive long-term memory (Aso and Rubin, 2016; Séjourné et al., 2011; Pai et al., 2013).”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “, 2004), and to be retrieved via α2sc (MB-V2) MBONs (Séjourné et al., 2011; Bouzaiane et al., 2015).”
Distinct dopamine neurons mediate reward signals for short- and long-term memories (2014, methodology): “For in vivo calcium imaging, female flies expressing GCaMP3 (60) with R48B04-GAL4 and R15A04-GAL4 were prepared essentially as described (19, 61).”