Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

By Zhong Li, Huiping Jiang, W. Xie, Zuchuan Zhang, A. Smrcka, Dianqing Wu. 2000

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Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice (2004, background): “…receptors (Stoyanov et al, 1995; Stephens et al, 1997; Wymann et al, 2000), and plays an important role in macrophage and neutrophil recruitment to inflammatory sites and in mast cell function (Hirsch et al, 2000; Li et al, 2000; Sasaki et al, 2000; Laffargue et al, 2002).”
Cell migration: Rho GTPases lead the way. (2004, background): “…migration towards colony-stimulating factor 1 (CSF-1) (Vanhaesebroeck et al., 1999), whereas type IB PI 3-kinases are required for neutrophil chemotaxis to a variety of inflammatory mediators that signal via G-protein-coupled receptors (Hirsch et al., 2000; Li et al., 2000; Sasaki et al., 2000).”
Signaling in innate immunity and inflammation. (2012, background): “Elevated intracellular calcium together with protein kinase C (PKC) activation by DAG is important for vesicle exocytosis, superoxide production by the NADPH oxidase, and JNK activation (Li et al. 2000).”
Dancing to the tune of chemokines (2001, background): “In the neutrophils of mice that lack the genes encoding PLC-β 2 and PLC-β 3 , the chemokine-induced calcium elevation is fully suppressed, which supports the conclusion that PLC-β 2 and PLC-β 3 are the sole PLC isoforms that are activated by chemokines in immune cell”