Expression pattern of Wnt signaling components in the adult intestine.

By A. Gregorieff, Daniel Pinto, H. Begthel, O. Destrée, M. Kielman, Hans Clevers. Gastroenterology, 2005

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Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, methodology): “Protocols for in vitro transcription and in situ hybridizations are described elsewhere (Gregorieff et al., 2005). b-galactosidase (LacZ) staining was done as described previously (Barker et al., 2007).”
The intestinal stem cell. (2008, background): “Multiple secreted Wnt factors are produced by the epithelial cells at the crypt bottom (Gregorieff et al. 2005), potentially generating a morphogen-like gradient of Wnt signals along the crypt–villus axis.”
Wnt/beta-catenin signaling in development and disease. (2006, neutral): “Wnt proteins are physiologically expressed by the crypt epithelial cells rather than by the surrounding mesenchyme (Gregorieff et al., 2005).”
Normal stem cells and cancer stem cells: the niche matters. (2006, background): “Wnt signaling is known to promote crypt cell proliferation (38); however, sFRP5, a Wnt inhibitor, has also been shown to be predominantly expressed in ISCs ( 39 ).”