Nanostructured lipid matrices for improved microencapsulation of drugs.

By R. Müller, M. Radtke, S. Wissing. International journal of pharmaceutics, 2002

1,100 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/3e3a4714ddec37f939fafa47501d248db4f22e0f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

In Molecular Biology

In Pharmaceutical Science

Citations in the corpus

Protein drug stability: a formulation challenge (2005, background): “Examples of lipid-based formulations with the potential for serving as delivery systems for macromolecules such as proteins include liposomes, solid lipid nanospheres and water-in-oil emulsion”
Nanostructured lipid carriers: Promising drug delivery systems for future clinics. (2016, background): “Oral bioavailability enhancement One of the most widely exploited routes of administration for NLCs exploitation has been the oral route.(3,4,90,91) Due to the increased drug loading capacity of NLCs, most of these studies have been focused on the ability of NLCs to improve the oral bioavailability ”
Vegetable proteins in microencapsulation: a review of recent interventions and their effectiveness (2013, background): “Various lipophilic substances such as glycerides, oils, phospholipids, carotenoids and waxes are also used as carrier materials in microencapsulation (Eldem et al., 1991; Lee et al., 2003; McClements et al., 2007; Muller et al., 2002; Patel et al., 2010).”
Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives (2007, methodology): “Three types of NLC have been described: I) imperfect type, II) amorphous type and III) multiple type (Figure 2) (Radtke and Müller 2001; Müller et al 2002a; Müller et al 2002b).”
Design and production of nanoparticles formulated from nano-emulsion templates-a review. (2008, background): “rates and lower these problems, using nanostructured lipid matrices [157] or lipid-drug conjugates [158].”
Innovative approaches for cancer treatment: current perspectives and new challenges (2019, background): “To overcome this issue, one or more lipids, liquid at room temperature (like oleic acid, for example), are included in the formulation [47].”
Nanoparticles as drug delivery systems (2012, background): “Additionally, some disadvantages have been observed, such as low loading capacity (limited by the solubility of drug in the lipid and the structure and polymorphic state of the lipid matrix), drug expulsion after crystallization, and a relatively high water content of the dispersions [104, 165].”
Microencapsulation: An overview on concepts, methods, properties and applications in foods (2021, background): “Some studies have shown that themicrocapsules formedby spray cooling are not very stable and it leads to expulsion of the core material during storage (Jenning et al., 2000;Müller et al., 2002).”
Strategies to Address Low Drug Solubility in Discovery and Development (2013, background): “NLCs incorporate blends of solid and liquid lipids (but retain solid properties at room temperature) that increase the drug-loading capacity of the lipid core (Muller et al., 2002).”
Targeted Delivery of Pesticides Using Biodegradable Polymeric Nanoparticles (2013, background): “As the drug-loading capacity of the particles relies essentially on the structure and the polymorphism of the lipid forming the nanoparticles, some new types of lipid particles exhibiting amorphous zones have been developed (Müller et al. 2002a; Wissing et al. 2004).”