Design and production of nanoparticles formulated from nano-emulsion templates-a review.

By N. Anton, J. Benoit, P. Saulnier. Journal of Controlled Release, 2008

1,136 citations recorded by the source corpus.

A considerable number of nanoparticle formulation methods are based on nano-emulsion templates, which in turn are generated in various ways. It must therefore be taken into account that active principles and drugs encapsulated in nanoparticles can potentially be affected by these nano-emulsion formulation processes. Such potential differences may include drug sensitivity to temperature, high-shear devices, or even contact with organic solvents. Likewise, nano-emulsion formulation processes must be chosen in function of the selected therapeutic goals of the nano-carrier suspension and its administration route. This requires the nanoparticle formulation processes (and thus the nano-emulsion formation methods) to be more adapted to the nature of the encapsulated drugs, as well as to the chosen route of administration. Offering a comprehensive review, this paper proposes a link between nano-emulsion formulation methods and nanoparticle generation, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation. The first part will deal with the nano-emulsion template through the different formulation methods, i.e. high energy methods on the one hand, and low-energy ones (essentially spontaneous emulsification and the phase inversion temperature (PIT) method) on the other. This will be followed by a review of the different families of nanoparticles (i.e. polymeric or lipid nanospheres and nanocapsules) highlighting the links (or potential links) between these nanoparticles and the different nano-emulsion formulation methods upon which they are based.

Subfields: Biomaterials, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/0d1e956ff2014c293a29d1e2b6a31e1028a4e7ae

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In Biomaterials

1. M. Hashemi
2. Jiajia Rao
3. D. McClements
4. C. Solans
5. K. El-Say
6. Hossam S. El-Sawy
7. I. Solé
8. T. Vandamme

In Pharmaceutical Science

1. C. Solans
2. I. Solé
3. D. McClements
4. Jiajia Rao
5. K. El-Say
6. Hossam S. El-Sawy
7. T. Vandamme
8. P. Sharma

Citations in the corpus

• Nanoemulsion: an advanced mode of drug delivery system (2014, methodology): “This technique makes use of highpressure homogenizer/piston homogenizer to produce nanoemulsion of extremely low particle size (up to 1 nm) (Asua 2002; Anton et al. 2008).”
• Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery (2011, background): “The lower the PI value, the more monodispered the nanoparticle dispersion is. Most of the researchers accept PI value less than 0.3 as optimum value (66, 67 ).”
• Polymeric nanoparticles: Promising platform for drug delivery. (2017, methodology): “9 polymers used is permitted to disperse through the emulsion continuous phase (Anton et al., 2008; Rao and Geckeler, 2011).”
• Nano-emulsions and Micro-emulsions: Clarifications of the Critical Differences (2011, methodology): “The many advantages of these systems lie in the selfemulsifying features of the processes themselves, which not only stem from their simplicity (as we will see below), but also from the very low energetic yields involved, thus showing great potential for use in industrial scaling-up (1, 2 ).”
• Nanoscience and nanotechnologies in food industries: opportunities and research trends (2014, methodology): “However, seen from a general point of view, they can be defined as nano-vesicular systems that exhibit a typical coreshell structure in which the drug is confined to a reservoir or within a cavity surrounded by a polymer membrane or coating (Anton et al. 2008).”