DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

By D. Crighton, S. Wilkinson, J. O'prey, N. Syed, PaulR . Smith, P. Harrison, M. Gasco, O. Garrone, T. Crook, K. Ryan. Cell, 2006

1,412 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3dfe318f474ee7a6ade01d5c2cf194689a6f6dcb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. D. Klionsky
4. N. Mizushima
5. I. Slaninová
6. Douglas R. Green
7. V. Deretic
8. Alec C. Kimmelman

In Molecular Biology

1. Guido Kroemer
2. Beth Levine
3. Douglas R. Green
4. L. Galluzzi
5. D. Klionsky
6. Craig B. Thompson
7. Simone Fulda
8. Alec C. Kimmelman

In Oncology

1. Guido Kroemer
2. R. Shaw
3. L. Galluzzi
4. D. Tang
5. M. V. Vander Heiden
6. Craig B. Thompson
7. Ralph J. Deberardinis
8. Scott J. Dixon

Citations in the corpus

• p53 and metabolism (2009, background): “Owing to reports of autophagy modulation during tumour development and in the control of metabolic stress, it is perhaps no surprise that several reports have now indicated that p53 can directly activate autophag”
• Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. (2007, background): “lysosomal protein required for fusion of autophagosomes (16).”
• Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “In addition, p53 has been shown to transactivate DRAM (damage-regulated autophagy modulator), a lysosomal protein that can stimulate the accumulation of autophagic vacuole”
• Recent insights into the function of autophagy in cancer (2016, background): “Indeed, p53 has been shown to play a role in a transcriptional program that activated multiple autophagy genes (Crighton et al. 2006; Guo et al. 2013b; Kenzelmann Broz et al. 2013; White 2016).”
• Autophagy in the pathogenesis of disease. (2008, neutral): “P53, the most commonly mutated tumor suppressor gene in human cancers, positively regulates autophagy in DNA-damaged cells, perhaps through AMPK activation of the TSC1/TSC2 complex and subsequent TOR inhibition or perhaps via upregulation of DRAM (damageregulated autophagy modulator), a lysosomal pr”
• Regulation of autophagy by cytoplasmic p53 (2008, background): “, presumably as a result of the p53-mediated transactivation of autophagy inducer”
• Autophagy in the Cellular Energetic Balance (2011, neutral): “Thus, p53 mediates the transcriptional upregulation of autophagy activators such as DRAM (damageregulated autophagy modulator) (Crighton et al., 2006) but at the same time cytosolic forms of p53 can directly repress autophagy by mechanisms still poorly characterized (Tasdemir et al.”