Interleukin 22 (IL‐22) plays a protective role in T cell‐mediated murine hepatitis: IL‐22 is a survival factor for hepatocytes via STAT3 activation

By S. Radaeva, R. Sun, Hong‐na Pan, F. Hong, B. Gao. Hepatology, 2004

630 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Oncology

View Paper: https://www.semanticscholar.org/paper/3dd73bbcb9ac62d9b82dbc0058b588e0de3669c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Flavell
2. Shomyseh Sanjabi
3. P. Murray
4. M. V. D. van den Brink
5. J. O’Shea
6. J. Dudakov
7. A. Hanash
8. Shizuo Akira

In Oncology

1. R. Flavell
2. P. Murray
3. J. O’Shea
4. Shomyseh Sanjabi
5. Ming O. Li

Citations in the corpus

• Interleukin-22: immunobiology and pathology (2015, background): “Hepatitis B Viral Liver Limits tissue damage (328, 330, 335, 397)”
• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “IL-22 protects the liver injury by enhancing the growth and survival of hepatocytes (Radaeva et al., 2004).”
• IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. (2008, background): “IL-22 serves as a strong activator of STAT3 (6, 8, 9).”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “Treatment with recombinant cytokine or gene therapy delivery of IL-22 may alleviate tissue destruction during inflammatory responses [50,52,64].”
• Cytokine signaling modules in inflammatory responses. (2008, background): “Additional studies in liver-damage models also support the notion that IL-22 plays an anti-inflammatory, protective role in the liver (Pan et al., 2004; Radaeva et al., 2004).”
• Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007, background): “A previous study suggested that IL-22 may play a protective role during acute liver inflammation (Radaeva et al., 2004).”
• Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease (2008, background): “IL-22 has been shown to be an important mediator in dermal inflammation (Ma et al., 2008; Zheng et al., 2007), and alternatively, it can provide protection to hepatocytes during liver inflammation (Radaeva et al., 2004; Zenewicz et al., 2007) and, as we now show here, IBD.”