Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective

By Michael R. Irwin. Annual Review of Psychology, 2014

1,169 citations recorded by the source corpus.

Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on antiviral immune responses with consequences for vaccine responses and infectious disease risk, and on proinflammatory immune responses with implications for cardiovascular disease, cancer, and depression. This review also discusses the neuroendocrine and autonomic neural underpinnings linking sleep disturbance and immunity, and the reciprocal links between sleep and inflammatory biology. Lastly interventions are discussed as effective strategies to improve sleep, and potential opportunities are identified to promote sleep health for therapeutic control of chronic infectious, inflammatory, and neuropsychiatric diseases.

Subfields: Behavioral Neuroscience, Endocrine and Autonomic Systems, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/d759f8bbeb16d0fa5077fc8d5439c63c7b49ee94

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Citations in the corpus

The Sleep-Immune Crosstalk in Health and Disease (2019, background): “To conclude, habitual short sleep duration and chronic sleep disturbances are related to a variety of diseases, including cardiovascular diseases, metabolic diseases, chronic pain conditions, some forms of cancer, and neuropsychiatric disease (255), all of which involve immune dysregulations.”
Inflammation: depression fans the flames and feasts on the heat. (2015, background): “Can normalize sleep (75) Patients with lower CRP responded”
Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation (2015, background): “Whereas no study has systematically evaluated whether elevated levels of inflammation mediate the association between sleep disturbance and cardiovascular disease or other diseases that have an inflammatory component including cancer and depression, extensive data show that sleep disturbance, as wel”
A Meta-Analysis of the Relationship Between Sleep Problems and Loneliness (2020, background): “Such data are concerning given that poor sleep has been linked with a range of physical and mental health problems (for review, see Ford & Kamerow, 1989; Irwin, 2015; Owens, 2007; Pigeon, Pinquart, & Conner, 2012; Sateia, Doghramji, Hauri, & Morin, 2000).”
Conséquences psychopathologiques du confinement (2020, background): “Il faut souligner par ailleurs qu’une réduction du temps de sommeil, qu’elle soit liée à un changement de rythme, un haut niveau de stress ou les deux, peut, d’une part, rendre les sujets plus vulnérables aux infections virales [60], augmenter le risque de troubles psychiatriques et addictifs [61], ”