Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

By Bin Wang, S. Matsuoka, Bryan A. Ballif, Dong Zhang, A. Smogorzewska, Steven P. Gygi, Stephen J. Elledge. Science, 2007

721 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3d208eb36865bb1c408af0ce1ca4aab2fd99e36c

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In Genetics

1. M. Jasin
2. Dana Branzei
3. M. Foiani

In Molecular Biology

1. J. Bartek
2. J. Lukas
3. Dana Branzei
4. M. Jasin
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8. M. Foiani

Citations in the corpus

• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. (2007, neutral): “Finally, chromatin retention of BRCA1 is also regulated by MDC1 (Bekker-Jensen et al., 2006; Lou et al., 2003) and requires at least two additional proteins, RAP80 and ABRA1 (Kim et al., 2007; Sobhian et al., 2007; Wang et al., 2007; Yan et al., 2007).”
• DNA damage sensing by the ATM and ATR kinases. (2013, background): “3B) (Huen et al. 2007; Kim et al. 2007a,b; Kolas et al. 2007; Mailand et al. 2007; Sobhian et al. 2007; Wang and Elledge 2007; Wang et al. 2007; Doil et al. 2009; Galanty et al. 2009; Morris et al. 2009; Stewart 2009; Bekker-Jensen et al. 2010; Meerang et al. 2011; Mattiroli et al. 2012).”
• Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins (2007, background): “In this regard, BRCA1 was recently shown to form a new complex with receptor-associated protein 80 (RAP80, also known as UIMC1 ) (Ref”
• An ATM-Dependent Transcriptional Silencing Program is Transmitted Through Chromatin in Cis to DNA Double Strand Breaks (2010, background): “These marks have been studied primarily as recognition signals for repair proteins (Kim et al., 2007; Sobhian et al., 2007; Wang et al., 2007).”
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. (2007, background): “Together, our study implicates RNF8 as a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and plays a critical role in the cellular response to genotoxic stress.”
• RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. (2009, positive): “RNF8 catalyzes local histone ubiquitylation and thereby renders the DSB-flanking chromatin permissive to assemble additional DSB regulators such as 53BP1 and BRCA1 (Huen et al., 2007; Kolas et al., 2007; Mailand et al., 2007; Sobhian et al., 2007; Wang et al., 2007; Wang and Elledge, 2007; Yan et ”
• Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “In addition to BRCA1, Abraxas binds to another component of the BRCA1-A complex RAP80, which recognizes polyubiquitylated histones like H2AX to recruit the BRCA1-A complex to DNA-damage sites (Kim et al. 2007; Sobhian et al. 2007; Wang et al. 2007).”
• BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “BRCA1 is directly involved in HR-mediated repair of DSB”
• The biological impact of mass-spectrometry-based proteomics (2007, background): “Abraxas was more heavily phosphorylated in irradiated cells than in non-irradiated cells, and it formed a complex with RAP80 (also known as UIMC1) and BRCA1, which was required for resistance to DNA damage, control of the cycle checkpoint at the G2–M boundary and repair of DN”
• Regulation of DNA repair throughout the cell cycle (2008, background): “that catalyses the formation of unusual polyubiquitin chains that are linked through Lys6 (these chains are often present at sites of DNA damage”
• Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis (2010, neutral): “As a result, the complexes formed between BRCA1 and BRCT-interacting proteins are functionally distinc”
• Ubiquitin-binding domains — from structures to functions (2009, background): “For example, receptor associated protein 80 (RAP80; also known as UIMC1) targets BRCA1 to DNA damage-induced foc”