The biological impact of mass-spectrometry-based proteomics

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Molecular approaches to study the insect gut symbiotic microbiota at the ‘omics’ age (2010, background): “Among the various proteomic techniques, mass spectrometry (MS)-based shot-gun proteomics has emerged as the primary method for the identification and quantification of protein expression (Cravatt et al., 2007).”
A draft map of the human proteome (2014, methodology): “The peptides identified were categorized either as (1) mapping intergenic regions (2) overlapping annotated genes (3) mapping to the intronic regions of existing gene models (4) overlapping annotated genes but translated in alternate reading frame.”
Mass Spectrometry-Based Label-Free Quantitative Proteomics (2009, background): “In addition to global profiling of the proteins present within a system at a given time, information on the level of protein expression is increasingly required in proteomics studies [1, 2].”