Use of Ly6G‐specific monoclonal antibody to deplete neutrophils in mice

By Jean M. Daley, A. Thomay, Michael D. Connolly, J. Reichner, J. Albina. Journal of Leukocyte Biology, 2008

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Regulatory interactions between muscle and the immune system during muscle regeneration. (2010, background): “One of the antibodies used for phenotyping, anti-Gr-1 binds Ly6G, which is expressed at high levels by neutrophils (19, 25, 38, 43, 103).”
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Murine neutrophils are defined as CD11b+ Ly6G+ cells (Daley et al., 2008).”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, methodology): “This contrasts with most previous studies that used the monoclonal antibody RB6-8C5 directed against the granulocyte receptor 1 (GR-1) surface antigen (Daley et al., 2008).”
A Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and the Complement Pathway (2011, methodology): “Serial mesio-distal sections (7 to 8 mm thick) parallel to the long axis of the teeth (sagittal) were stained with FITC-conjugated monoclonal antibody to mouse Ly6G (LifeSpan BioSciences), a specific neutrophil marker (Daley et al., 2008).”
Tumor entrained neutrophils inhibit seeding in the premetastatic lung (2011, positive): “To unequivocally assess their contribution, neutrophils were depleted using the Ly-6G antibody shown in previous studies to effectively and specifically deplete neutrophils (Daley et al., 2008).”