Cell interactions with three-dimensional matrices.

By E. Cukierman, R. Pankov, Kenneth M. Yamada. Current Opinion in Cell Biology, 2002

907 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3cdadf2b93b51431447afac742713656647eaba4

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Citations in the corpus

• Fibronectin Matrix Assembly Regulates α5β1-mediated Cell Cohesion (2003, background): “ture often differ in shape, signaling, and behavior from those grown in a 3D system (Cukierman et al., 2002).”
• Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP (2004, background): “Similarly, although recent reports posit a preeminent role for MMP-2 in degradative events after its TIMP-2–dependent activation by MT1-MMP (Brinckerhoff and Matrisian, 2002; Seiki et al., 2003), MMP-2 / as well as TIMP-2 / fibroblasts also mount normal collagenolytic responses, effectively…”
• A distinctive role for focal adhesion proteins in three-dimensional cell motility (2010, background): “When cells are partially embedded in a 3D matrix, focal adhesions become smaller and their composition differs from the conventional 2D cas”
• Modeling tissue morphogenesis and cancer in 3D. (2007, unknown): “Numerous studies have analyzed the bidirectional mechanosensory responses of fibroblasts or myofibroblasts to collagen gels (Cukierman et al., 2002; Discher et al., 2005; Ghosh et al., 2007; Grinnell, 2003; Orr et al., 2006).”
• Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. (2010, background): “Typically, flat surfaces, compared to tissues or 3D systems, force cells to adapt to abnormal microenvironmental conditions, which can then lead to altered cell responses [8,70].”
• Focal adhesion kinase: in command and control of cell motility (2005, background): “Moving in three dimensions As adherent cells in culture readily make focal contacts, these points of cell adhesion undergo a maturation process to form fibrillar adhesions and they will form three-dimensional (3D) adhesions when cells are placed in a 3D environmen”
• 3D cell culture opens new dimensions in cell-based assays. (2009, unknown): “14 Cukierman, E. et al. (2002) Cell interactions with three-dimensional matrices.”
• Local force and geometry sensing regulate cell functions (2006, background): “Recent studies have determined that the same matrix protein will elicit a different response when it is organized in filaments from when it is displayed on a flat surfac”
• The comet assay: a method to measure DNA damage in individual cells (2006, background): “With growing evidence that the 3D matrix environment plays an important role in facilitating cell respons”
• Focal adhesion regulation of cell behavior. (2004, background): “While the previous adhesions have been described for cells adhering to rigid 2D surfaces, 3D matrix adhesions have been defined for fibroblasts adhering to 3D cell-derived fibronectin matrices [2,13] and collagen gels [14] and epithelial cells in 3D collagen [15,16].”
• Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis (2003, background): “Rounded motility does not require pericellular proteolysis It was recently demonstrated that amoeboid tumour cell motility can occur even after inhibition of extracellular proteases, including matrix metalloproteases (MMPs”
• Bioactive Modification of Poly(ethylene glycol) Hydrogels for Tissue Engineering (2010, background): “In turn, these receptor-ligand interactions trigger complex cascades of intracellular enzymatic reactions that regulate gene and protein expression, and define the fate of a cell in a tissue [84].”