Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.

By J. Dwyer, H. Allayee, K. Dwyer, Jingxu Fan, Huiyun Wu, R. Mar, Aldons J. Lusis, M. Mehrabian. New England Journal of Medicine, 2004

651 citations recorded by the source corpus.

Subfields: Biochemistry, Nutrition and Dietetics, Pharmacology

View Paper: https://www.semanticscholar.org/paper/3cb12aa50b39b58d281a7fef2a98bfaa509c3197

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. A. Simopoulos
2. A. Tedgui
3. Z. Mallat
4. J. Keaney

In Nutrition and Dietetics

1. Antonio Ceriello
2. A. Simopoulos
3. K. Esposito
4. D. Giugliano
5. J. Keaney

Citations in the corpus

• Reactive Oxygen Species in Cardiovascular Disease (2011, background): “Given the available data in animal models, lipoxygenases have been investigated with regards to human cardiovascular disease [95].”
• The effects of diet on inflammation: emphasis on the metabolic syndrome. (2006, background): “In a randomly sampled cohort of 470 healthy middle - aged women and men from the Los Angeles Atherosclerosis Study ( 23 ) , increased dietary intake of omega - 3 fatty acids was associated with a blunted effect of the variant 5 - lipoxygenase genotype ( lacking the com - mon allele ) to increase car”
• The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases (2008, background): “hypothesized that a polymorphism in the 5lipoxygenase gene promoter could relate to atherosclerosis in humans, and that this effect could interact with the dietary intake of competing 5-lipoxygenase substrates (75).”
• Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. (2006, background): “When humans ingest fish or fish oil, the EPA and DHA from the diet partially replace the omega-6 fatty acids, especially AA, in the membranes of probably all cells, but especially in the membranes of platelets, erythrocytes, neutrophils, monocytes, and liver cells (reviewed in Ref.”
• The role of oxidative stress in atherosclerosis. (2009, methodology): “This hypothesis led to clinical trials for the examination of their action in cardiovascular diseases.(31,32)”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “Furthermore, clinical findings showed that variant alleles of 5-LO genes were associated with a significant increase of carotid intima thickness (184).”