The validity of animal models of depression

By P. Willner. Psychopharmacology, 2004

956 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/3c0cd9d46fb79e68f7511f7efb85f46ad75a9d4a

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In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Social Psychology

Citations in the corpus

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant (2004, background): “Although a large number of behavioural paradigms have been proposed as animal models of depression, only a small minority can lay claim to a degree of validity sufficient for them to be considered as potentially useful research tools (Willner 1984).”
Forced swimming test in mice: a review of antidepressant activity (2004, methodology): “Because the pharmacotherapy of depression typically requires chronic drug treatment to obtain a full response, face validity (Willner 1984) takes account of the necessity, or not, to use chronic administration to have an antidepressant effect and the specificity of observed features.”
The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, methodology): “These principles were first proposed in relation to animal models of depression (Willner, 1984) and the CMS model was the first model to be systematically investigated using this framework, as summarized in a review of the first ten years of CMS research (Willner, 1997).”
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure (2006, background): “Although we believe that construct validity is desirable, it is important to keep in mind that very few of the widely used animal models of psychiatric disorders meet criteria for construct validity (Geyer and Markou 1995; Willner 1984, 1997).”
Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment (2003, background): “In this model, exposure to inescapable stress, in this case footshock, results in an inability to escape shock in a subsequent avoidance test (AT) (Willner, 1984; Thiebot et al, 1992; Cryan et al, 2002).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Thus, the FST is sensitive to the immediate effects of antidepressants and does not reflect the delayed onset of therapeutic response of these treatments in depressed humans (Willner, 1984).”
Is the forced swimming test a suitable model for revealing antidepressant activity? (2004, background): “In fact, a) the majority of antidepressants reduce immobility time and their effectiveness correlates significantly with clinical potency (Willner 1984) and b) it is sufficiently specific, since it discriminates antidepressants from neuroleptics and anxiolytics.”