Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

By P. Willner, A. Towell, D. Sampson, S. Sophokleous, R. Muscat. Psychopharmacology, 2004

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The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “…weekly, showed a reduced consumption of, and preference for, weak solutions of saccharin or sucrose, which developed over the course of several weeks exposure, and that the decreased sucrose preference was restored by 2e4 weeks of treatment with a tricyclic antidepressant (Willner et al., 1987).”
Dopamine System Dysregulation in Major Depressive Disorders (2017, background): “…by an increased immobility time in the forced swim test, which relates to “behavioral despair” or resignation, and with a decrease in sucrose preference, which is suggested as a hedonic deficit (Katz, 1982), often described in animals exposed to CMS (Willner et al., 1987; Tye et al., 2013).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “, 1979) and the chronic unpredictable stress (CUS) model (Willner et al., 1987).”