Chromatin remodelling during development

By Lena Ho, G. Crabtree. Nature, 2010

1,109 citations recorded by the source corpus.

New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues. In addition to DNA methylation and histone modification, ATP-dependent enzymes that remodel chromatin are important controllers of chromatin structure and assembly, and are major contributors to the dynamic nature of chromatin. Evidence is emerging that these chromatin-remodelling enzymes have instructive and programmatic roles during development. Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3bf476af4a80b0a26c4ef109131cc1b9e447784f

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Citations in the corpus

Control of Embryonic Stem Cell State (2011, background): “Differentiation is also accompanied by modifications in the subunit composition of mediator, BAF, and TFIID complexes (Deato et al., 2008; Deato and Tjian, 2007; Ho and Crabtree, 2010; Taatjes, 2010).”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “Many specialized sets of nuclear proteins, which are not involved in chromatin modifications per se, are also critical for epigenetic regulation (146, 147).”
Cancer Genetics and Epigenetics: Two Sides of the Same Coin? (2012, background): “In addition to SWI/SNF complexes, mutations of other ATP dependent chromatin remodelers are beginning to be identified in several cancers (Clapier and Cairns, 2009; Hargreaves and Crabtree, 2011; Ho and Crabtree, 2010).”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “…leading to a present-day consensus model for selective gene control (Adelman and Lis, 2012; Bannister and Kouzarides, 2011; Bonasio et al., 2010; Conaway and Conaway, 2011; Fuda et al., 2009; Ho and Crabtree, 2010; Roeder, 2005; Spitz and Furlong, 2012; Taatjes, 2010; Zhou et al., 2012b).”
Protein Networks as Logic Functions in Development and Cancer (2011, background): “Another example of network-encoded logic is the BAF chromatin remodeling complex [8].”
ATP-dependent chromatin remodeling during mammalian development (2016, background): “BAF complexes are similar to yeast SWI/SNF complexes, but are more diverse in their subunit composition and have roles both in activation and repression of genes, performing key functions during development (Ho and Crabtree, 2010; Wang et al., 1996).”
Epigenetic modifications and human disease (2010, background): “These complexes, known as chromatin remodeling complexes, can be classified into four families (SWI/SNF, ISWI, CHD and INO80) that share similar ATPase domains but differ in the composition of their unique subunit”
Lessons from the cancer genome. (2013, positive): “CHD proteins regulate chromatin compaction during stem cell differentiation and may also promote genome stability (Ho and Crabtree, 2010) (Figure 2).”