Lessons from the cancer genome.

By Levi A. Garraway, Eric S. Lander. Cell, 2013

1,271 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/74000bef4d2fc0589297f9ba32d52ad9d7bca089

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Citations in the corpus

Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018, background): “Advances in DNA sequencing over the past decade have made it possible to systematically study these genetic changes, and we now have a better understanding of the commonly involved processes and signaling pathways (Garraway and Lander, 2013; Vogelstein et al., 2013).”
Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade (2016, background): “Mutational load and tissue context determine cellular composition of immune infiltrates The vision of precision oncology implies patient specific genomic profiling and testing of targeted therapeutics on the subset of patients carrying the relevant genetic lesions, rather than on patients selected b”
SvABA: genome-wide detection of structural variants and indels by local assembly (2018, background): “SVs are an important source ofvariation in thehu-man population (Sudmant et al. 2015) and substantially alter the structure of the genome in cancer (Beroukhim et al. 2010; Garraway and Lander 2013).”
Evolution of the cancer stem cell model. (2014, background): “The last 6 years have seen a ﬂood of whole exome sequencing (WES) and whole genome sequencing (WGS) of thousands of tumors, enabling complex analyses of the mutations that are present within a single tumor and across multiple tumors (Garraway and Lander, 2013).”
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma (2016, background): “Large-scale cancer sequencing efforts have advanced our understanding of the genomic landscape of many malignancies (Garraway and Lander, 2013).”
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis (2015, background): “A major challenge in understanding the cancer genome is to disentangle alterations that are driving the processes of tumor evolution from passenger mutations (Garraway and Lander, 2013).”