Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

By Hao Wu, V. Coskun, Jifang Tao, Wei Xie, W. Ge, K. Yoshikawa, E. Li, Yi Zhang, Y. Sun. Science, 2010

627 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b9f0e839bc639e346a7a629f50ffbd3613cfb73

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Guo-li Ming
2. Hongjun Song
3. Hao Wu
4. Yi Zhang
5. Alexander Meissner
6. Jean-Pierre Issa
7. Grant A. Challen
8. Christoph Bock

In Molecular Biology

1. Hao Wu
2. Hongjun Song
3. Guo-li Ming
4. Yi Zhang
5. Christoph Bock
6. Allison M. Bond
7. Alexander Meissner
8. H. Gu

Citations in the corpus

• Neuronal activity modifies DNA methylation landscape in the adult brain (2011, background): “, emerging evidence suggests diverse roles of DNA methylation in various contexts, including promoting gene expressio”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “…development and activity-dependent DNA demethylation Brain-specific deletion of DNA methyltransferases results in premature death, neural developmental defects, and impaired neuronal functions (Fan et al. 2001, 2005; Nguyen et al. 2007; J Feng et al. 2010; LaPlant et al. 2010; Wu et al. 2010).”
• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “…in neurodevelopmental deficits and impaired neuronal functions (Fan et al., 2001; Fan et al., 2005; Feng et al., 2010a; LaPlant et al., 2010; Nguyen et al., 2007; Wu et al., 2010), suggesting that precise control of DNA methylation pattern is required for proper brain development and maturation.”
• Dnmt3a is essential for hematopoietic stem cell differentiation (2011, background): “In neural progenitors, Dnmt3a has been shown to enable the expression of neurogenic genes through gene-body methylatio”
• Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “Oligodendrocyte precursors migrate to the corpus callosum to myelinate axons (Figure 4) (Xing et al., 2014).”
• Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, background): “DNMT3A can facilitate gene transcription by methylating nonpromoter regions including intergenic regions and gene bodie”