Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.

By Tian Xia, M. Kovochich, M. Liong, Huan Meng, Sanaz Kabehie, S. George, J. Zink, A. Nel. ACS Nano, 2009

861 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b6eddcf385c41d49b455222441d0d3d4d8bffb5f

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Citations in the corpus

• Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, background): “For instance, surface coating with polyethyleneimine of mesoporous silica nanoparticles enhances the cellular uptake and allows safe delivery of siRNA and DNA constructs [156].”
• Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and Pgp siRNA to Overcome Drug Resistance in a Cancer Cell Line (2010, unknown): “It is well-known that PEI exerts cytotoxic effects when used by itself or attached to the nanoparticle surface as a polyplexing agent.(5) In this regard, we have recently demonstrated that the 25 kD PEI polymer as well as high doses of the 10 kD polymer can render the MSNP toxic as a result of the p”