CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal.

By O. Schulz, A. Edwards, M. Schito, J. Aliberti, S. Manickasingham, A. Sher, C. Reis e Sousa. Immunity, 2000

662 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b5660b12269803ae1753b03aacbd82216c3c26e

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In Immunology

1. Yong‐jun Liu
2. R. Steinman
3. C. Reis e Sousa
4. A. Lanzavecchia
5. F. Sallusto
6. G. Trinchieri
7. K. Shortman
8. H. Hemmi

In Molecular Biology

1. F. Sallusto
2. Takashi Kadowaki
3. R. Steinman
4. A. Lanzavecchia
5. C. Reis e Sousa

Citations in the corpus

• Dendritic-cell control of pathogen-driven T-cell polarization (2003, background): “cgi?l=959">CD40L , which is rapidly expressed by the T cells after their activation by the DC-derived signals 1 and 2 (Ref”
• PI3K-mediated negative feedback regulation of IL-12 production in DCs (2002, methodology): “Splenic DCs were purified from PI3K +/+ and PI3K −/− mice and stimulated to induce IL-12 with the IL-12–inducing agents SAC ( Staphylococcus aureus Cowan I strain) and anti-CD40 in the presence or the absence of coinducers of IL-12, IFN-γ and/or IL-”
• Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “IL-12 production by DCs is tightly controlled, as it requires first a priming signal provided by microbial products or IFN-γ and then an amplifying signal provided by T cells through CD40 ligand (CD40L”
• Interleukin-12 and the regulation of innate resistance and adaptive immunity (2003, background): “, although production of IL-12 heterodimer is facilitated by stimulation through CD40”
• Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “In addition, activated T cells also increase IL-12 p70 production by interacting with DCs through CD40L–CD40 interaction”
• Dendritic cells: translating innate to adaptive immunity. (2006, background): “Is the production of inflammatory cytokines (e.g., TNF-α, IL-6, IL-12, interferons) one of the most critical means whereby DCs translate innate to different forms of adaptive immunity?”
• IL-12/IL-18-Dependent IFN-γ Release by Murine Dendritic Cells1 (2001, background): “respond to CD40 ligation with IL-12 release (28).”