Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells1

By G. Hartmann, A. Krieg. Journal of Immunology, 2000

641 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3b236476e9d7ddd6f9965fe72f89806fb6f655d9

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In Immunology

1. Shizuo Akira
2. Satoshi Uematsu
3. A. Krieg
4. Yong‐jun Liu
5. D. Klinman
6. R. Medzhitov
7. K. Ishii
8. V. Hornung

Citations in the corpus

• Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells1 (2001, background): “293 stimulated with CpG ODN that activate human PBMC (9, 10) significantly increased NF- B dependent luciferase activity (Fig.”
• Immunotherapeutic uses of CpG oligodeoxynucleotides (2004, background): “'K'-type ODNs (also known as CpG-B) encode multiple CpG motifs on a phosphorothioate backbone, and trigger the differentiation of APCs and the proliferation and activation of B cell”
• Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “more CpG motifs on a phosphorothioate backbone (27, 28).”
• Therapeutic potential of Toll-like receptor 9 activation (2006, background): “This results in the rapid activation of several mitogen-activated protein kinases, including extracellular receptor kinase (ERK), p38 , and Jun N-terminal kinase, as well as the IκB complex, and these pathways converge on the nucleus to alter gene transcriptio”
• Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo1 (2000, background): “We identified a potent human CpG motif, 59-GTCGTT-39, by testing phosphodiester ODN for the ability to stimulate human primary B cells (29) and found that *Department of Internal Medicine, University of Iowa, Iowa City, IA 52242; CpG ImmunoPharmaceuticals GmbH, Hilden, Germany; Loeb Health Research ”
• Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens (2001, neutral): “minnesota serotype Re595 (Sigma-Aldrich), 50 g/ml poly (I:C) (Sigma-Aldrich), 5 M (46 g/ml) phosphodiester CpG-oligodeoxynucleotide ( ODN) AAC-30 (21, 22).”
• Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 (2005, background): “Similarly, the 6mer CpG motif needs to be part of a longer oligonucleotide to become an active TLR9 ligan”