Protection from septic shock by neutralization of macrophage migration inhibitory factor

By Thierry Calandra, B. Echtenacher, D. L. Roy, J. Pugin, C. Metz, L. Hültner, D. Heumann, D. Männel, R. Bucala, M. Glauser. Nature Medicine, 2000

797 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3b0aca3cac486464308188f40f6549965274df29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Bucala
2. A. Manfredi
3. P. Noble
4. T. Roger
5. M. Bianchi
6. E. Lolis
7. Thierry Calandra

Citations in the corpus

• High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity (2007, background): “No other treatment is effective so late: antibodies against the macrophage migration inhibitory factor are effective up to 8 h after cecal perforation, and anti-TNF-a antibodies actually increase mortality (21).”
• MIF Signal Transduction Initiated by Binding to CD74 (2003, background): “MIF-induced secretion of PGE 2 secretion into medium was measured by specific ELISA (10).”
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “Interest in the biology of MIF has been heightened by the protein’s role in septic shock (Bernhagen et al., 1993; Calandra et al., 2000), by the description of functional polymorphisms in the gene that are associated with inflammatory disease (Gregersen and Bucala, 2003), and by an emerging role…”
• Macrophage migration inhibitory factor: a regulator of innate immunity (2003, background): “Increased levels of MIF have been detected in the blood of patients with severe sepsis or septic shock 60, 79, 83, 84 .”
• Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “Mouse modeling and human clinical studies have implicated MIF in the pathogenesis of various acute and chronic inflammatory diseases, including septic shock [79], asthma [165], rheumatoid arthritis [166], atherosclerosis [167], inflammatory bowel disease [168], and cancer [76].”