Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

By Tatsuki Sugiyama, H. Kohara, Mamiko Noda, T. Nagasawa. Immunity, 2006

2,050 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/332eb1f76d4bc35c423da89f5e8f4d9b07a70d41

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. S. Morrison
2. G. Semenza
3. P. Frenette
4. A. Caplan
5. P. Robey
6. P. Bianco
7. T. Suda
8. Lei Ding

In Immunology

1. S. Morrison
2. P. Frenette
3. Miriam Merad
4. A. Keating
5. D. Hashimoto
6. G. Semenza
7. A. Spradling

In Oncology

1. S. Morrison
2. A. Spradling
3. T. Suda
4. Fanxin Long
5. A. Keating
6. K. Takubo
7. A. Caplan
8. Shenghui He

Citations in the corpus

• Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow (2009, methodology): “The following antibodies were used as a primary antibodies; anti-GFP (rabbit IgG; 1:500; MBL; and goat IgG; 1:200; Santa Cruz Biotechnology, Inc.), -SMA (1A4; FITC or Cy3conjugated; Sigma-Aldrich), Sca-1 (D7; BD), PDGFR (Santa Cruz Biotechnology, Inc.), Ang-1 (Santa Cruz Biotechnology, Inc.), CXCL12”
• Arteriolar niches maintain haematopoietic stem cell quiescence (2013, neutral): “The high proportion of HSCs near sinusoids is consistent with previous reports 18,19 .”
• Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, neutral): “, 2005b), but are believed to be surrounded by SDF1-expressing adventitial cells (Kiel and Morrison, 2006; Sugiyama et al., 2006) and/or F4/80 clusters of myeloid cells (Sapoznikov et al.”
• Leptin Receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow (2014, neutral): “The high expression of Cxcl12 (Figure S1E) and PDGFRa (Figures 1L and 1M) by LepR stromal cells indicates that these cells overlap strongly with CAR cells, which are also found primarily around sinusoids throughout the bone marrow (Omatsu et al., 2010; Sugiyama et al., 2006).”
• Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “(B) Schematic representation of outcomes following HIF-1a or VHL deletion in HSCs. of the BM suggests that 60% of LT-HSCs reside adjacent to the vasculature (Kiel et al., 2005; Sugiyama et al., 2006).”
• Mechanisms of stem cell self-renewal. (2009, background): “…of mouse HSCs depends on a series of stem cell–extrinsic factors in the bone marrow including Steel factor (Thoren et al. 2008), CXCL12 (Nie et al. 2008, Sugiyama et al. 2006), Thrombopoietin (Qian et al. 2007, Yoshihara et al. 2007), and Angiopoietin-1 (Arai et al. 2004, Puri & Bernstein 2003).”