FOXOs: signalling integrators for homeostasis maintenance
By A. Eijkelenboom, B. Burgering. Nature reviews. Molecular cell biology, 2013
1,072 citations recorded by the source corpus.
Subfields: Aging, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/3a9c98c0cca14e7305e0723a064d9b72d96153ab
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
- A. Dinkova-Kostova
- Rute Martins
- W. Link
- J. Campisi
- Jan H. J. Hoeijmakers
- G. Lithgow
- Y. Fouad
- C. Aanei
In Molecular Biology
- A. Dinkova-Kostova
- Claudio Franceschi
- J. Hayes
- M. Conte
- Jeroen Essers
- Daniela Monti
- Andrea Grignolio
- K. Tew
Citations in the corpus
- Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “The genetic contribution of lifespan increases with greater age, particularly after the age of 60, reaching estimates of 33% in women and 48% in men living to at least 100 (Sebastiani & Perls, 2012; Brooks-Wilson, 2013).”
- Oxidative Stress in Cancer (2020, background): “Besides responding to ROS, FOXOs also respond to nutrients and regulate genes involved in cell-cycle arrest, such as GADD45, and apoptosis (Eijkelenboom and Burgering, 2013).”
- Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy (2015, neutral): “FoxOs are involved in a variety of biological process such as autophagy, apoptosis, ROS detoxification, glucose metabolism, DNA repair, cell cycle, stem cell maintenance and longevity 19,20 .”
- Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “FOXOs are well studied in aging and tissue homeostasis as targets of insulin/ IGF signaling and as regulators of reactive oxygen species (de Keizer et al., 2011; Eijkelenboom and Burgering, 2013; Martins et al., 2016).”
- The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “The activation of the IGF-1/AKT/mTOR pathway suppresses autophagy, but it also counteracts activation of FOXO transcription factors, which are central regulators of metabolism, cell-cycle progression and programmed cell death (85).”