Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids

By D. Czock, F. Keller, F. Rasche, U. Häussler. Clinical Pharmacokinetics, 2005

872 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy (2017, background): “5 h to reach its peak plasma concentration, hence the rapid clinical effect, but despite a short plasma half-life is considered a long-acting steroid with a biological half-life of 36–54 h [95, 116].”
Toxicities of chimeric antigen receptor T cells: recognition and management. (2016, positive): “Dexamethasone is often chosen in this context because of its excellent CNS penetration (Table 3).(69) We give dexamethasone for grade 3 neurologic toxicities other than headaches lasting more than 24 hours, grade 4 neurologic toxicities of any duration, and for any seizures.”
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. (2016, background): “Because of the short plasma half-life of hydrocortisone (approximately 90 min) (90), multiple dosing is recommended to mimic physiological conditions.”