Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
By Lars Bertram, M. McQueen, K. Mullin, Deborah Blacker, Rudolph E. Tanzi. Nature Genetics, 2007
1,885 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3a19b36d7f41ba20a507dee2585fd56fa019167a
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In Computational Theory and Mathematics
- Berislav Zlokovic
- Rudolph E. Tanzi
- G. Bu
- J. Herz
- John P. A. Ioannidis
- Jason H. Moore
- John Hardy
- Clifford R. Jack Jr.
In Molecular Biology
- D. Holtzman
- Berislav Zlokovic
- G. Bu
- Rudolph E. Tanzi
- John C. Morris
- Mark T. W. Ebbert
- Perry G. Ridge
- John S. K. Kauwe
Citations in the corpus
- Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders (2011, background): “Importantly, a recent longitudinal CBF study in neurologically normal individuals revealed that people bearing the apolipoprotein E (APOE) ɛ 4 allele — the major genetic risk factor for late-onset Alzheimer's diseas”
- Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses (2008, background): “, none of these candidates has been proved to consistently influence disease risk or onset age in more than a handful of sample”
- Identifying Neuroimaging and Proteomic Biomarkers for MCI and AD via the Elastic Net (2011, background): “Apolipoprotein E (ApoE) is a major genetic risk factor for AD [1].”
- Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, positive): “Since then, numerous studies have confirmed that the 14 allele is the strongest genetic risk factor for both AD and CAA, or a combination of both disorders (Schmechel et al. 1993; Greenberg et al. 1995; Bertram et al. 2007).”
- Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort (2010, methodology): “org) of candidate genes for AD, curated by Lars Bertram and colleagues (Bertram et al., 2007), provides a regularly updated source for determining the replication and validation status of AD genes.”
- Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention (2009, result): “Several other candidate genes, many of them vascular related such as angiotensin-I converting enzyme, cholesterol 24-hydroxylase, and insulin-degrading enzyme genes, have been studied, but with inconsistent findings.(44,45)”
- Replication in genome-wide association studies (2009, background): “Examples include the field synopses on Alzheimer’s disease (AlzGene database), schizophrenia (SzGene database) and DNA repair genes [3, 63].”
- Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. (2012, neutral): “org) (Bertram et al. 2007).”
- Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “most important genetic risk factor in LOAD after APOE [475].”
- Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database (2008, neutral): “DRD4 Jonsson, 2003 rs1800955 1,459 (3) 3,988 (6) C vs.”
- Systematic Review: Factors Associated With Risk for and Possible Prevention of Cognitive Decline in Later Life (2010, methodology): “We developed a separate search strategy for the genetics literature by examining the HuGEpedia (1) and AlzGene (2) databases to identify relevant systematic reviews for genes identified as being of special interest, in consultation with the technical expert panel.”