Transforming Grown Factor-β Signaling in Immunity and Cancer

By E. Batlle, J. Massagué. Immunity, 2019

1,884 citations recorded by the source corpus.

Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironments, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/dbf706623d39d79e0328b733be96d03af7839ece

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1. Qingcai Meng
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4. Xianjun Yu
5. C. Meyer
6. Steven Dooley
7. Jin Xu
8. Chen Liang

Citations in the corpus

• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Substantial studies have proven that CAF-secreted TGF-β significantly inhibits the activation and cytotoxic activity of NK cells [192].”
• TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019 (2019, background): “AVID200 represents a computationally designed highly potent trap for TGF-β1 and TGF-β3 [278].”