Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

By Michael Egan, Terry E. Goldberg, Bhaskar S. Kolachana, J. Callicott, C. Mazzanti, R. Straub, D. Goldman, Daniel R. Weinberger. Proceedings of the National Academy of Sciences of the United States of America, 2001

2,445 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/39f92c5d059e8ce97bab13e1e1595251fc40dd2e

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Citations in the corpus

Discovering Endophenotypes for Major Depression (2004, background): “In healthy humans and schizophrenic patients, a functional polymorphism of the COMT gene appeared to explain some of the individual variance in working memory performance (Egan et al, 2001; Malhotra et al, 2002).”
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation (2009, background): “The finding of impaired working memory function in val-val individuals is consistent with the classic inverted-U-shaped dogma (Egan et al. 2001) but also with the view that the val-val phenotype may be associated with enhanced distractibility and switching (Bilder et al. 2004).”
Intermediate phenotypes and genetic mechanisms of psychiatric disorders (2006, methodology): “Neuroimaging studies using a reliable activator for the PFC — the n -back working memory task — have shown that this coding variant affects PFC activatio”
Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance (2003, result): “More generally, our current findings along with those of other recent studies (Bookheimer et al., 2000; Egan et al., 2001; Hariri et al., 2002), highlight the potential of functional neuroimaging as an approach for exploring the biological impact of genetic variation on information processing within”
Evolutionary Biology of Animal Cognition (2004, methodology): “A standard test of working memory revealed highly significant effects of the COMT genotype, with the Val/Val scoring lowest and Met/Met scoring highest (Egan et al. 2001).”
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “…far have examined associations of COMT genotype with various cognitive abilities in healthy individuals and/or people with schizophrenia (Bilder et al, 2002; Diamond et al, 2004; Egan et al, 2001; Goldberg et al, 2003; Joober et al, 2002; Malhotra et al, 2002; Nolan et al, 2004; Tsai et al, 2003).”