Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion.

By Y. Bryceson, M. March, H. Ljunggren, Eric O Long. Blood, 2006

872 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/39f3a210e6ac4e987adeaf7291b6ff1e2b06479a

How researchers see this paper

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In Immunology

1. D. Raulet
2. L. Lanier
3. Eric O Long
4. É. Vivier
5. S. Ugolini
6. H. Ljunggren
7. Y. Bryceson
8. M. March

Citations in the corpus

• CAR-NK cells: A promising cellular immunotherapy for cancer (2020, background): “[6] In addition to their roles as cytotoxic effector cells, activated NK cells also secrete various inflammatory cytokines and chemokines, which in turn recruit and activate other immune cells such as T cells, dendritic cells, and macrophages.”
• Functions of natural killer cells (2008, background): “Similarly, resting human peripheral blood NK cells harbor poor effector functio”
• Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “…or cytokines (e.g., type I interferons or their synthetic inducers) or culture NK cells ex vivo in the presence of cytokines (e.g., IL-2, IL-15) to elicit detectable effector functions prior to in vitro analyses of NK cell responses (Bryceson et al., 2006; Djeu et al., 1979; Gidlund et al., 1978).”
• Up on the tightrope: natural killer cell activation and inhibition (2008, background): “In a series of elegant experiments, Long and colleagues demonstrated that when agonist antibodies are used to cross-link the 'activating' receptors on freshly isolated primary human NK cells, none of the receptors alone, with the exception of CD16, are able to elicit cytolytic activity or cytokine s”
• Regulation of ligands for the NKG2D activating receptor (2013, background): “However, naive human NK cells failed to respond well when stimulated through NKG2D alone, but did respond well when NKG2D was stimulated along with other receptors such as 2B4, a SLAM family receptor whose ligand is broadly expressed by hematopoietic cells (11).”
• The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy (2017, background): “Using cross-linking antibodies to NK receptors, it has been shown that only CD16 alone could trigger degranulation of resting human NK cells while most activating receptors such as NKG2D and NCRs could perform activation only in combination with other receptors (76, 77).”
• Controlling NK Cell Responses: Integration of Signals for Activation and Inhibition (2013, background): “primary, resting NK cells with NKp46 Abs was not sufficient to activate degranulation (18).”
• Activation, coactivation, and costimulation of resting human natural killer cells (2006, background): “Interestingly, analysis of monoclonal antibodies to NKG2D, DNAM-1, 2B4, and CD2with resting NK cells demonstrated that these receptors do not induce efficient lysis (66).”