CAR-NK cells: A promising cellular immunotherapy for cancer
By Guozhu Xie, Han Dong, Yong Liang, J. D. Ham, Romee Rizwan, Jianzhu Chen. EBioMedicine, 2020
662 citations recorded by the source corpus.
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the remarkable success of chimeric antigen receptor (CAR)-engineered T (CAR-T) cells for treating haematological malignancies, there is a rapid growing interest in developing CAR-engineered NK (CAR-NK) cells for cancer therapy. Compared to CAR-T cells, CAR-NK cells could offer some significant advantages, including: (1) better safety, such as a lack or minimal cytokine release syndrome and neurotoxicity in autologous setting and graft-versus-host disease in allogenic setting, (2) multiple mechanisms for activating cytotoxic activity, and (3) high feasibility for ‘off-the-shelf’ manufacturing. CAR-NK cells could be engineered to target diverse antigens, enhance proliferation and persistence in vivo, increase infiltration into solid tumours, overcome resistant tumour microenvironment, and ultimately achieve an effective anti-tumour response. In this review, we focus on recent progress in genetic engineering and clinical application of CAR-NK cells, and discuss current challenges and future promise of CAR-NK cells as a novel cellular immunotherapy in cancer.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/12bbb51ae888c7cde52f83f70e4b837645bf2866
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Citations in the corpus
- Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation (2021, background): “In humans, the level of cytolytic activity of circulating NK cells correlates with the risk of cancer (277) and infiltration of NK cells in some cancers is associated with a better prognosis (278, 279).”