Neuropathology of older persons without cognitive impairment from two community-based studies

By David A. Bennett, Julie A. Schneider, Zoe Arvanitakis, J. Kelly, N. Aggarwal, R. Shah, R. Wilson. Neurology, 2006

1,292 citations recorded by the source corpus.

Subfields: Epidemiology, Psychiatry and Mental health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/39f31aeb025fcfb49f1dc15ab4e34507e597ffb7

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In Epidemiology

In Psychiatry and Mental health

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

β-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease (2007, background): “The stronger relationship of ADrelated pathological changes to episodic memory compared with other cognitive domains is consistent with previous post-mortem research (Nagy et al., 1996; Thomas et al., 2005; Bennett et al., 2006).”
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. (2009, background): “The general trend amongst post-mortem and PIB-PET studies is to divide normal subjects into low-and high-pathology groups (Hulette et al., 1998; Schmitt et al., 2000; Goldman et al., 2001; Jack et al., 2002; Bennett et al., 2006; Mintun et al., 2006; Rowe et al., 2007; Fotenos et al., 2008).”
Neuropathological alterations in Alzheimer disease. (2011, background): “Longitudinal prospective clinicopathological studies in nondemented elderly people have revealed that up to 45% of nondemented elderly would meet the NIA-RI criteria for AD had they been demented, usually the intermediate likelihood category of these criteria, and rarely the high likelihood category”
Classification and basic pathology of Alzheimer disease (2009, result): “found, in their ‘‘normal’’ population, cases that met the criteria for AD but, with refined testing, concluded that, even in the so-called pre-symptomatic phase, AD lesions (in the intermediate or high probability range of the NIA Reagan criteria, see later) were associated with subtle alterations o”
PET Imaging of Tau Deposition in the Aging Human Brain (2016, neutral): “Neuropathological studies have repeatedly demonstrated that these aggregated proteins also accumulate in the brains of cognitively healthy older people (Bennett et al., 2006; Davis et al., 1999).”
Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease (2009, background): “Postmortem neuropathological studies find significant fibrillar A burden in many older people who were cognitively normal (2, 4, 5).”
Religious Orders Study and Rush Memory and Aging Project (2018, positive): “A dozen years ago we first reported that pathologic AD was present in about a third of older persons without dementia or MCI and that it was related to episodic memory [55].”