Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

By V. Palma, Daniel A. Lim, N. Dahmane, P. Sánchez, Thomas C. Brionne, Claudia D. Herzberg, Y. Gitton, A. Carleton, Arturo Alvarez-Buylla, A. R. I. Altaba. Development, 2005

644 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/09973eead1164e27bf666029b2d4e121ef847af5

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In Developmental Neuroscience

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Citations in the corpus

Hedgehog Signaling in Development and Cancer (2008, neutral): “The Hh pathway has been extensively analyzed in neural stem and progenitor cells (Ahn and Joyner, 2005; Balordi and Fishell, 2007; Dahmane et al., 2001; Lai et al., 2003; Machold et al., 2003; Palma et al., 2005; Wechsler-Reya and Scott, 1999).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Two mitogens widely used to culture neural stem cells in vitro either as neurospheres or as adherent monolayers are epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) (Reynolds & Weiss 1992; Palmer et al. 1995).”
The biology of cancer stem cells. (2007, background): “The Shh signaling pathway is crucial to the embryonic development of skin, hair follicles, and sebaceous glands (Athar et al. 2006) and is involved in postnatal and adult brain development (Palma et al. 2005).”
Presenilin 1 mutants impair the self-renewal and differentiation of adult murine SVZ-neuronal progenitors via cell autonomous mechanisms involving Notch signaling (2010, background): “…microglia (Walton et al., 2006), endothelial cells (Leventhal et al., 1999; Shen et al., 2004) or astrocytes (Song et al., 2002; Lie et al., 2005; Palma et al., 2005; Jiao and Chen, 2008) and that differences in the microenvironment and signaling pathways govern the two adult neurogenic niches…”
Adult neurogenesis and the olfactory system. (2009, background): “Many of these factors also have important roles in embryonic development, such as sonic hedgehog (Shh), which is expressed in the SVZ and regulates cell proliferation by acting on both GFAP-expressing stem cells, and transit-amplifying cells (Palma et al., 2005).”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “Alternatively, adult SEZ stem cells may be exposed to local domains of niche factors such as BMP and Sonic hedgehog (Palma et al., 2005; Colak et al., 2008), thereby creating distinct progenitor domains with different fate restrictions.”
Basal cell carcinomas: attack of the hedgehog (2008, background): “One potential on-target adverse effect might be on normal tissue stem cells such as those of the brain, the maintenance of which in mice is supported by H”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “Shh signaling has been shown to be important for the proliferation and maintenance of adult neural stem cells (Lai et al., 2003; Machold et al., 2003; Palma et al., 2005).”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, result): “That all actions of Hh signaling are not confined to B cells seems probable, as both the present work and previous findings (Ahn and Joyner, 2005; Palma et al., 2005) have shown that Hh signaling is also activated in C cells.”
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “…growth factor (FGF), epidermal growth factor (EGF), and the transforming growth factor (TGFb), all of which have been shown to affect self-renewal capacity both c. in vivo and in vitro (Battista et al., 2006; Doetsch et al., 2002a; Jin et al., 2003; Palma et al., 2005; Reya et al., 2003).”
Brain tumour stem cells (2006, background): “Similarly, Sonic Hedgehog ( SHH ) and its downstream effectors glioma-associated oncogene homologue 1 ( GLI1 ), GLI2 and GLI3 have been shown to specifically regulate neurogenesis and self-renewal within the external granular layer of the early postnatal cerebellum and to control precursor proli”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “The transcription factor gli1, which indicates high levels of pathway activation, is expressed predominantly in the ventral half of the VZ-SVZ (Machold et al., 2003; Palma et al., 2005), a region that is associated with the generation of deep granule interneurons and calbindin-positive PGCs (Ihrie e”