Dopamine depletion impairs precursor cell proliferation in Parkinson disease

By G. Höglinger, P. Rizk, M. Muriel, C. Duyckaerts, W. Oertel, I. Caillé, E. Hirsch. Nature Neuroscience, 2004

982 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/6634176ba94ea717b61511bb5492ea762657a08c

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Citations in the corpus

Neurodegenerative disease and adult neurogenesis (2011, background): “These findings have been reported in 6-hydroxydopamine (6-OHDA)-lesioned rats by several groups (Baker et al., 2004; Hoglinger et al., 2004; Winner et al., 2006).”
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-born Dentate Granule Cells (2011, background): “It has been proposed that dopamine (DA) controls the proliferation of neural precursor cells (NPCs) in the SGZ, although conflicting results have been reported (Höglinger et al., 2004; Domínguez-Escribá et al., 2006; Park and Enikolopov, 2010).”
Toxin-induced models of Parkinson’s disease (2005, result): “The 6-OHDA model has also been used successfully to demonstrate the importance of dopamine stimulation for the proliferation of precursor cells in both the subependymal and the subgranular zones of the adult brain in rats.(46) It also allowed to demonstrate that, contrary to earlier reports, there i”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “TH-positive dopaminergic neurites have also been reported to contact VZ-SVZ progenitors directly, with a high percentage of these neurites appearing in association with EGFR-positive type C cells (Hoglinger et al., 2004).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “in PD individuals and correlated with a–synuclein accumulation [119, 120].”
Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers (2017, background): “, 2006) and Parkinson’s disease (Hoglinger et al., 2004) where stem cell proliferation”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “Similar to serotonergic effects, denervation of dopaminergic neurons decreases proliferation of NSCs in the SGZ (Hoglinger et al., 2004).”
Association of olfactory dysfunction with risk for future Parkinson's disease (2008, background): “Dopamine depletion impairs precursor cell proliferation in rodents, and reduced numbers of these cells have been documented in the subventricular zone in the brains of PD cases.(40) Olfactory deficits in PD may not entirely be related to pathology in the olfactory structures.”
Adult Neurogenesis in Humans. (2015, background): “Deprivation of neurogenesis in the human olfactory bulb has been implicated in several neurodegenerative diseases that compromise olfaction and can lead to anosmia (Turetsky et al. 2000; Höglinger et al. 2004; Hansson et al. 2010; Negoias et al. 2010; Winner et al. 2011).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Many signals, including dopamine (Hoglinger et al. 2004), soluble amyloid precursor protein (Caille et al. 2004), nitric oxide (Estrada et al. 1997; Matarredona et al. 2005) and Shh (Ahn & Joyner 2005; Palma et al. 2005), converge on the transit-amplifying cells and act cooperatively with…”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “Dopaminergic signaling may promote SVZ proliferation in vivo through the D2-like dopamine receptors (Hoglinger et al., 2004).”
Hippocampal neurogenesis: regulation by stress and antidepressants. (2006, background): “Neurogenesis also occurs in the subventricular zone, but SRIs and TCAs have no effect on SVZ neurogenesis (Malberg et al 2000; Santarelli et al 2003); however, there appears to be a role for dopamine in regulating SVZ neurogenesis (Hoglinger et al 2004; Kippin et al 2005).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Further, experimental depletion of dopamine in a rodent model of Parkinson’s disease (PD) has been reported to decrease precursor cell proliferation in both the SVZ and the dentate gyrus (Hoglinger et al. 2004).”