Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

By M. Drab, P. Verkade, M. Elger, M. Kasper, Matthias Lohn, Birgit Lauterbach, J. Menne, C. Lindschau, F. Mende, F. Luft and 3 more. Science, 2001

1,609 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3931fd49aae222e0ca4635a9331012de7e9e8144

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. U. Förstermann

In Cell Biology

1. John Hancock
2. Robert G. Parton
3. K. Simons
4. M. A. Pozo
5. P. Le
6. M. Lisanti
7. I. Nabi
8. E. Cukierman

In Molecular Biology

1. John Hancock
2. K. Simons
3. Robert G. Parton
4. M. A. Pozo
5. Tian Xia
6. A. Nel
7. M. Liong
8. J. Zink

Citations in the corpus

• Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. (2008, background): “It has previously been shown that caveolae affect cellular viability by interfering in cellular proliferation signals.(31) It is also known that caveolae affect intracellular Ca(2) flux and mitochondrial function.”
• PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. (2008, background): “Caveolae are absent from nonmuscle tissues of Cav1 / animals (Drab et al., 2001) and ectopic expression of Cav1 in cells lacking caveolae leads to de novo caveolae formation (Fra et al.”
• The multiple faces of caveolae (2007, background): “The ability to experimentally manipulate caveolins, which are essential for caveola formatio”
• Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms (2003, background): “Caveolin-1 null mice showed no difference in albumin levels in cerebrospinal fluid, suggesting that transendothelial albumin transport was normal (10).”
• Caveolae/raft-dependent endocytosis (2003, background): “Caveolae are not observed in endothelial cells of caveolin-1 knock-out mice, although some smooth caveolaelike invaginations were reported (Drab et al., 2001; Razani et al., 2001; Zhao et al., 2002).”
• Role of caveolae and caveolins in health and disease. (2004, methodology): “Isolated aortic rings from Cav-1 null animals were unable to establish a steady-state contractile tone, oscillating at a frequency of once per minute (40).”
• Biomechanical remodeling of the microenvironment by stromal Caveolin-1 favors tumor invasion and metastasis (2011, methodology): “Disturbed fibroblast function might underlie pulmonary fibrosis, hypertension, and cardiac fibrosis and hypertrophy in Cav1KO mice (Drab, 2001; Razani et al., 2001; Zhao et al., 2002).”
• Endothelial dysfunction in diabetes mellitus (2007, neutral): “Addition of oxidized LDL to cultured endothelial cells disrupts the caveolae complex and is thought to be associated with decreased endothelial NOS activity and endothelial dysfunction (Blair et al 1999; Drab et al 2001).”
• Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. (2003, neutral): “In aortas from caveolin knockout mice, on the other hand, the relaxant response to acetylcholine is enhanced and the constrictor response to phenylephrine blunted as a consequence of enhanced basal NO production (29, 103).”