Caveolae/raft-dependent endocytosis

By I. Nabi, P. Le. Journal of Cell Biology, 2003

791 citations recorded by the source corpus.

Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e360063d282a094b0b186f441931cf66f2ddac45

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Citations in the corpus

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. (2010, background): “Genistein is a tyrosinekinase inhibitor and this agent causes local disruption of the actin network at the site of endocytosis and inhibits the recruitment of dynamin II, both known to be indispensible events in the caveolae mediated uptake mechanism [31,32].”
Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae (2011, background): “Flattening and Disassembly of Caveolae upon Hypo-Osmotic Shock The contribution of caveolae to the general endocytic activity of the cell is believed to be minimal (Nabi and Le, 2003), and endocytosis is disfavored at high membrane tension (Dai et al.”
Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms (2003, background): “A recent review proposes that internalization via caveolae or internalization via lipid rafts are fundamentally similar processes (109).”
Subcellular targeting strategies for drug design and delivery (2010, background): “However, some viruses, such as simian vacuolating virus 40 (SV40), mediate their entry into the nucleus by retrogradely trafficking from the plasma membrane to the ER followed by transfer to the nucleu”
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling (2005, neutral): “— overexpressing caveolin-1 reduces caveolar endocytic rate”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “scaffolding domains to the plasma membrane and dynamin2 (also required in CME) activity enable assembly and expansion of caveolar endocytic vesicles (78,100,101).”