Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity

By R. Cancello, J. Tordjman, C. Poitou, G. Guilhem, J. Bouillot, D. Hugol, C. Coussieu, A. Basdevant, Avner Bar Hen, P. Bedossa and 2 more. Diabetes, 2006

607 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology

View Paper: https://www.semanticscholar.org/paper/390cc36c126b0002788517a2aed7e9fe4fe22432

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. P. Calder
2. Alan R. Saltiel
3. M. Blüher
4. Gerald I. Shulman
5. B. Spiegelman
6. E. Rosen
7. V. Samuel

In Epidemiology

1. Alan R. Saltiel
2. C. Lumeng
3. Myung‐Sook Choi
4. U. Jung
5. S. Fried
6. P. Calder
7. Jennifer L Bodzin
8. M. Blüher

Citations in the corpus

• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, positive): “On the other hand, it seems likely that reduced secretion of pro-inflammatory mediators from adipocytes or activated macrophages of adipose tissue contributes to the effect of weight loss((31,36,65,67,142)).”
• Adipose tissue dysfunction in obesity. (2009, background): “In addition, macrophage infi ltration into omental fat, but not into subcutaneous fat, was shown to be associated with clinical parameters of obesity co-morbidity ( Harman-Boehm et al., 2007 ), as well as with the severity of histological changes in liver biopsies ( Cancello et al., 2006 ).”
• Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “Macrophage infiltration is associated with insulin resistance, metabolic syndrome, and morbidity (Cancello et al., 2006; Harman-Boehm et al., 2007).”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “CLS are also more numerous in visceral than sc in human (Cinti et al. 2005;Cancello et al. 2006;Harman-Boehm et al. 2007).”
• High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway (2012, background): “Macrophages that infiltrate into the adipose tissue are responsible for TNFa, inducible nitric oxide synthases (iNOS), and IL-6 expression [8,11].”
• Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “In contrast, visceral adipose tissue is positively associated with risk of insulin resistance and shows higher monocytes infiltration and IL-6 production than subcutaneous adipose tissue to induce inflammation in obese subjects (Cancello et al., 2006; Fontana et al., 2007).”
• Obesity induces a phenotypic switch in adipose tissue macrophage polarization. (2007, background): “Moreover, weight loss leads to a reduction in both inflammatory markers and ATM content (4, 7).”
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “Although it is known that during the development of obesity macrophages infiltrate in adipose tissue, it now appears that the infiltration rate of monocytes into visceral adipose tissue is higher than into subcutaneous adipose tissue (Figure 2).(32) A”
• Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “circulating triglyceride levels in obese patients, and a negative relationship has been found with plasma HDL cholesterol levels [186].”