Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

By P. Cohen, M. Miyazaki, Nicholas D. Socci, A. Hagge-Greenberg, W. Liedtke, A. Soukas, Ratnendra Sharma, L. Hudgins, J. Ntambi, J. Friedman. Science, 2002

804 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/38d1b884c2f93579873777d9488befe1dae599a2

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In Endocrine and Autonomic Systems

In Nutrition and Dietetics

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Citations in the corpus

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. (2005, background): “Introduction Maintenance of energy homeostasis and body weight involves the coordinated regulation of appetitive behavior and peripheral energy metabolism (1), as illustrated by the ability of the appetitereducing hormone leptin to regulate fat metabolism in the liver (2).”
Energy Metabolism in the Liver (2014, positive): “Global knockout of SCD1, which catalyzes the synthesis of monounsaturated LCFAs, protects against obesity (39, 193).”
Molecular mediators of hepatic steatosis and liver injury. (2004, positive): “The genetic deletion of SCD-1, an enzyme responsible for the synthesis of monounsaturated fatty acids, protects against the development of fatty livers and insulin resistance in mice (47, 48).”
AMPK in Health and Disease. (2009, methodology): “The mammalian AMPK domain limits were established experimentally by partial proteolysis (395), and a stable rat 1(68-163) fragment was expressed and crystallized in the presence of -cyclodextrin (an 1-4 linked heptaglucan), as had previously been performed for other starch binding domain structural ”
Enzymes of triacylglycerol synthesis and their regulation. (2004, background): “Because SCD-1 activity is increased 7-fold in ob/ob mice, asebia SCD1 / –ob/ob mice were studied [178].”
Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease (2016, background): “Mice with a global knockout of stearoyl-CoA desaturase are protected from a high-carbohydrate high-fat (HCHF) diet-induced or genetically induced obesity and show decreased lipogenic gene expression coupled with increased b-oxidation [70, 71].”
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions (2007, background): “Moreover, simultaneous disruption of both Adipor1 and Adipor2 significantly increased the expression levels of genes encoding molecules involved in fatty acid synthesis, such as Scd1 (ref”
Fibroblast growth factor 21 corrects obesity in mice. (2008, background): “Importantly, SCD1-null animals are lean, metabolically fit, and have lower liver fat content (18), similar to the phenotype of FGF21-treated DIO animals.”
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. (2010, background): “induction of obesity by diet [84] or leptin deficiency [87].”
Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. (2009, background): “In lean tissues this effect was exerted through down-regulation of SREBP-1c mRNA levels (22, 40).”