Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.

By G. Feldmann, S. Dhara, V. Fendrich, D. Bedja, R. Beaty, M. Mullendore, Collins A. Karikari, H. Alvarez, C. Iacobuzio-Donahue, A. Jimeno and 3 more. Cancer Research, 2007

696 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Oral Surgery

View Paper: https://www.semanticscholar.org/paper/e77e1b7ff8306fd4e2bd1183e497549d5fed9b1e

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In Molecular Biology

1. C. V. Dang
2. J. P. Thiery
3. M. Nieto
4. G. Semenza
5. R. Huang
6. R. Weinberg
7. Angeliki Voulgari
8. A. Pintzas

In Oncology

1. J. P. Thiery
2. M. Nieto
3. R. Huang
4. Angeliki Voulgari
5. A. Pintzas
6. H. Acloque
7. N. Desai
8. C. V. Dang

Citations in the corpus

• Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “regulation and up-regulation of E-cadherin in cells with tumourinitiating properties and EMT [223,224].”
• EMT and tumor metastasis (2015, background): “These findings suggest that inhibition of the Hh pathway is a valid therapeutic strategy for pancreatic cancer that particularly targets metastasis [64,65].”
• Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression (2010, background): “7 grew significantly faster than P198, it was also sensitive to FX11 as a single agent (29) (Fig.”
• Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer (2009, background): “Increased ALDH1 activity has been found in stem cell populations in human multiple myeloma, acute myeloid leukemia, and brain and breast cancers (10-17).”
• Epithelial-mesenchymal transitions in development and disease. (2009, background): “Similarly, the inhibition of the Sonic hedgehog-Gli-Snail pathway with cyclopamine has been tested in xenograft mouse models of pancreatic carcinoma (Feldmann et al., 2007) and in gastrointestinal neuroendocrine tumors (Shida et al.”
• Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. (2011, methodology): “Quantitative Real-Time PCR Endothelial cell content was quantified by real-time polymerase chain reaction (qRT-PCR) for murine-specific nestin (mNestin) transcripts.(24) For qRT-PCR, total RNA was isolated (RNeasy Mini Kit, Qiagen, Santa Clarita, CA), followed by cDNA production (SuperScript III Fir”