In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

By Akihisa Matsuyama, Tadahiro Shimazu, Y. Sumida, A. Saito, Yasuhiro Yoshimatsu, D. Seigneurin-Berny, H. Osada, Y. Komatsu, N. Nishino, S. Khochbin and 2 more. EMBO Journal, 2002

728 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/38b5082d96915b62b9ab0b57121144d9379a8e47

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Citations in the corpus

• Post-translational modifications regulate microtubule function (2003, unknown): “By contrast, two enzymes that catalyse the opposing reaction — that is, deacetylation — have been recently describe”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, unknown): “CBP acetylates FoxO1 at Lys245, Lys248, and Lys265 (Figure 4A) (Matsuzaki et al., 2005).”
• DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells (2017, background): “Since TUBULIN acetylation has a role in microtubule dynamics and stabilization during cell polarization (Matsuyama et al., 2002), we studied microtubule and cytoskeleton organization in the rosettes.”
• The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “HDAC6 has been shown to function as an α-tubulin deacetylas”
• HDAC6 modulates cell motility by altering the acetylation level of cortactin. (2007, background): “…IH -PA Author M anuscript Discussion Results from previous studies have shown that HDAC6 associates with and regulates the acetylation of α-tubulin and Hsp90 (Bali et al., 2005; Haggarty et al., 2003; Hubbert et al., 2002; Kovacs et al., 2005; Matsuyama et al., 2002; Zhang et al., 2003).”
• Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “On the other hand, n-butyrate, trapoxin, FK228, and MS-275 cannot inhibit HDAC6 (a Class IIb enzyme), suggesting a difference in structure of the catalytic pockets between Class IIb and other enzymes (Matsuyama et al. 2002).”
• Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. (2004, background): “Consistent with this idea, HDAC6 deacetylates the cytoplasmic protein tubulin.(10,58,59) In addition, HDAC10 is reported to associate with HDAC3 and SMRT,(40,60) while HDAC6 apparently lacks these associations and instead associates with the class 4 HDAC11 protein.”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “Of the sirtuins, only SIRT2 deacetylates tubulin, also a target of the class II deacetylase HDAC6 (Hubbert et al., 2002; Matsuyama et al., 2002; North et al., 2003).”
• HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, unknown): “…to this process, we considered the possibility that the acetylated -tubulin commonly used to visualize cilia might play an active role in stabilizing the ciliary axoneme, based on reports that -tubulin deacetylation promoted the in vivo destabilization of microtubules (Matsuyama et al., 2002).”