HDAC6 modulates cell motility by altering the acetylation level of cortactin.

By X. Zhang, Zhigang Yuan, Yingtao Zhang, S. Yong, A. Salas-Burgos, John M. Koomen, N. Olashaw, J. Parsons, Xiang-Jiao Yang, Sharon Y. R. Dent and 3 more. Molecules and Cells, 2007

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Erasers of histone acetylation: the histone deacetylase enzymes. (2014, background): “HDAC6 is responsible for this deacetylation and thus influences actindependent motility in cancer cells (Zhang et al. 2007).”
Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “The identity of the responsible acetyltransferase(s) remains elusive, and it remains unclear how cell signaling might regulate this PTM. Cortactin Acetylation Cortactin acetylation was recently reported (Zhang et al., 2007).”
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men (2008, background): “, unpublished observations), whereas HDAC6 was found to associate with cytoskeletal proteins and chaperones”
Histone Deacetylase Inhibitors: Potential in Cancer Therapy (2009, background): “Specific inhibition of HDAC6 activity or its downregulation by siRNA increases accumulation of acetylated a-tubulin and cortactin and is associated with inhibition of cell migration [Zhang et al., 2007].”
HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy (2010, background): “While the HDAC6–actin interaction has been primarily linked to regulation of cell motility (Gao et al, 2007; Zhang et al, 2007), its association with the microtubule network and ubiquitinated proteins has led to the surprising finding that HDAC6 is a regulatory component of aggresome, the MTOC…”