Post-translational modifications regulate microtubule function
By S. Westermann, K. Weber. Nature reviews. Molecular cell biology, 2003
737 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/291313bf86edc45bb83b8086b32836fa123b8b84
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Citations in the corpus
- Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “a-tubulin was among the first acetylated nonhistone proteins to be discovered (Westermann and Weber, 2003).”
- Tracking the ends: a dynamic protein network controls the fate of microtubule tips (2008, background): “In most eukaryotic cells, the C-terminal EEY/F tail of α-tubulin is subject to a detyrosination–tyrosination cycle, in which the C-terminal Tyr is repeatedly cleaved and added back ( Box 2 ; reviewed in Ref”
- Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions (2011, background): “The wide range of PTMs (both those that are unique to tubulin and those that are shared with other proteins) might, alone or in combination, generate chemical differences that are sufficient to confer specific cellular functions on microtubule”
- EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration (2004, background): “Stabilized microtubules accumulate post-translationally modified tubulin, such as detyrosinated tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidas”
- Differential Expansion and Expression of α- and β-Tubulin Gene Families in Populus1[W][OA] (2007, background): “PTMs afford a means to modulate tubulin diversity and MT dynamics in animals (for review, see MacRae, 1997; Westermann and Weber, 2003).”
- Microtubule acetylation promotes kinesin-1 binding and transport. (2006, background): “One potential biochemical cue is microtubule PTMs, such as detyrosination, acetylation, and polyglutamylation, that occur after microtubule polymerization and accumulate on a subset of more stable microtubules in an age-dependent manner [6, 7].”