Wapl controls the dynamic association of cohesin with chromatin.

By Stephanie Kueng, Björn Hegemann, Beate H. Peters, Jesse J. Lipp, Alexander Schleiffer, K. Mechtler, J. Peters. Cell, 2006

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The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner (2007, neutral): “This step of cohesin removal depends on Wapl (Gandhi et al., 2006; Kueng et al., 2006) and the phosphorylation of the SA1/2 subunit of the cohesin complex (Hauf et al.”
Shared and separate functions of polo-like kinases and aurora kinases in cancer (2010, background): “In prophase and prometaphase cohesin removal from the chromosome arms is regulated by the cohesin-binding protein wings apart-like homologue (WAPL”
Chromatin organization by an interplay of loop extrusion and compartmental segregation (2017, background): “Cohesin is loaded onto eukaryotic DNA, assisted by Nipbl (31), while WAPL limits its residence time (32, 33).”
Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins (2017, positive): “WAPL is known to bind PDS5A and PDS5B (Kueng et al, 2006).”
Cohesin: its roles and mechanisms. (2009, background): “To answer these questions, it will be important to (a) determine atomic structures of the Smc3 NBD-kleisin interface, the non-Smc proteins Scc3, Scc2/4, Wapl, and Pds5; (b) develop in vitro systems that recapitulate key steps in cohesin’s association with chromatin fibers; and (c) develop assays to ”