Furin at the cutting edge: From protein traffic to embryogenesis and disease

By G. Thomas. Nature reviews. Molecular cell biology, 2002

1,210 citations recorded by the source corpus.

Subfields: Biotechnology, Cell Biology

View Paper: https://www.semanticscholar.org/paper/383fa9c0ae7c32a6f5dabdb77e407892c3b2e718

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Gary R. Whittaker
2. J. Millet
3. W. Parks
4. H. Ra

In Cell Biology

1. Lars Juhl Jensen
2. Gary R. Whittaker
3. J. Millet
4. Jannick Dyrløv Bendtsen
5. W. Parks
6. H. Ra
7. Søren Brunak

Citations in the corpus

• Fusion Protein Linkers: Property, Design and Functionality (2012, background): “Furin is mainly localized in the trans-golgi network (TGN) and also recycles between TGN, early endosomes, and the cell surface [69].”
• Control of matrix metalloproteinase catalytic activity. (2007, background): “Furin is a type 1 membrane, subtilisin-like serine protease present in the trans-Golgi network (Thomas, 2002), and thus, MMPs with a furin cleavage site are processed intracellularly before secretion (Illman et al., 2003;Kang et al., 2002;Pei and Weiss, 1995;Sato et al., 1996).”
• Neurotrophin secretion: current facts and future prospects. (2003, background): “The second group consists of PACE4, PC5/6B, PC7, and furin, which mostly contain a single transmembrane domain near the C-terminus and which are selectively found in the TGN, endosomes, and in rare cases also in constitutive secretory vesicles (Zhou et al., 1999; Thomas, 2002).”
• Feature-based prediction of non-classical and leaderless protein secretion. (2004, background): “This is puzzling, since propeptide cleavage usually takes place in secreted proteins (Thomas, 2002).”
• Host cell proteases: critical determinants of coronavirus tropism and pathogenesis (2014, background): “Because furin can be viewed as a representative PC (Thomas, 2002), and because it is the most frequently characterized PC to be involved in processing and activating coronavirus S proteins, we will focus on this protease.”
• Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease (2015, background): “Furin and furin-like proprotein convertases are broadly expressed serine endoproteases that cleave the multibasic motifs RX(R/K/X)R and process proproteins into their biologically active forms (55).”